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KMID : 1161420160190050457
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Journal of Medicinal Food
2016 Volume.19 No. 5 p.457 ~ p.465
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Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats
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Akinwumi Kazeem A.
Osifeso Olabode O.
Jubril Afusat J.
Adedoja Ayobami W.
Ogunbiyi Elizabeth T.
Adebo Fumilayo M.
Adesina Idayat O.
Odunola Oyeronke A.
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Abstract
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Exposure to hexavalent chromate compounds such as other human carcinogens is unavoidable in the developing countries of the world. Research efforts are being directed toward minimizing exposure to them, intercepting their activity in vivo, and/or prophylaxis. The present study therefore evaluates the effect of methanol extract of the leafy vegetable, Corchorus olitorius (MECO), against potassium dichromate (K2Cr2O7)-induced toxicities. Negative control animals were fed distilled water, while the positive control rats received 12?mg/kg body weight K2Cr2O7 once a week for 6 weeks. Test rats were exposed daily to 25, 50, and 100?mg/kg body weight MECO alone for 6 weeks and 12?mg/kg body weight of K2Cr2O7 once a week for 6 weeks before sacrifice. The frequency of micronucleated polychromatic erythrocytes (mPCEs) was monitored in bone marrow cells, while induction of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine levels, and hematological parameters were assessed in the plasma. The phytochemical analysis of MECO was also carried out. K2Cr2O7 significantly (P?
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KEYWORD
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creatinine, haematological parameters, hepatoprotection, hexavalent chromate, liver function markers, micronucleus, urea
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